Extended stability of cyclin D1 contributes to limited cell cycle arrest at G1-phase in BHK-21 cells with Japanese encephalitis virus persistent infection
Identifieur interne : 000732 ( new/Analysis ); précédent : 000731; suivant : 000733Extended stability of cyclin D1 contributes to limited cell cycle arrest at G1-phase in BHK-21 cells with Japanese encephalitis virus persistent infection
Auteurs : Ji Young Kim ; Soo Young Park ; Hey Rhyoung Lyoo ; Eung Seo Koo ; Man Su Kim ; Yong Seok JeongSource :
- Journal of Microbiology (Seoul, Korea) [ 1225-8873 ] ; 2015.
Abstract
There is increasing evidence that many RNA viruses manipulate cell cycle control to achieve favorable cellular environments for their efficient replication during infection. Although virus-induced G0/G1 arrest often delays early apoptosis temporarily, a prolonged replication of the infected virus leads host cells to eventual death. In contrast, most mammalian cells with RNA virus persistent infection often escape cytolysis in the presence of productive viral replication. In this study, we demonstrated that the extended endurance of cyclin D1 was clearly associated with the suppression of glycogen synthase kinase-3ß (GSK-3ß) expression in BHK-21 cells that are persistently infected with Japanese encephalitis virus (JEV). The G0/G1 arrest of these cells turned much loose compared to the normal BHK-21 cells with JEV acute infection. After cycloheximide treatment, cyclin D1 in the persistently infected cells lasted several hours longer than those in acutely infected cells. Furthermore, both p21Cip1 and p27Kip1, positive regulators for cyclin D1 accumulation in the nucleus, were suppressed in their expression, which contrasts with those in JEV acute infection. Inhibition of the GSK-3ß by lithium chloride treatment rescued a significant number of cells from cytolysis in JEV acute infection, which coincided with the levels of cyclin D1 that escaped from proteolysis. Therefore, the limitation of G1/S arrest in the BHK-21 cells with JEV persistent infection is associated with the suppression of GSK-3ß expression, resulting in the extended duration of cyclin D1.
Url:
DOI: 10.1007/s12275-015-4661-z
PubMed: 25557483
PubMed Central: 7090764
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Although virus-induced G0/G1 arrest often delays early apoptosis temporarily, a prolonged replication of the infected virus leads host cells to eventual death. In contrast, most mammalian cells with RNA virus persistent infection often escape cytolysis in the presence of productive viral replication. In this study, we demonstrated that the extended endurance of cyclin D1 was clearly associated with the suppression of glycogen synthase kinase-3ß (GSK-3ß) expression in BHK-21 cells that are persistently infected with Japanese encephalitis virus (JEV). The G0/G1 arrest of these cells turned much loose compared to the normal BHK-21 cells with JEV acute infection. After cycloheximide treatment, cyclin D1 in the persistently infected cells lasted several hours longer than those in acutely infected cells. Furthermore, both p21<sup>Cip1</sup> and p27<sup>Kip1</sup>, positive regulators for cyclin D1 accumulation in the nucleus, were suppressed in their expression, which contrasts with those in JEV acute infection. Inhibition of the GSK-3ß by lithium chloride treatment rescued a significant number of cells from cytolysis in JEV acute infection, which coincided with the levels of cyclin D1 that escaped from proteolysis. Therefore, the limitation of G1/S arrest in the BHK-21 cells with JEV persistent infection is associated with the suppression of GSK-3ß expression, resulting in the extended duration of cyclin D1.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alt, J R" uniqKey="Alt J">J.R. Alt</name></author><author><name sortKey="Gladden, A B" uniqKey="Gladden A">A.B. Gladden</name></author><author><name sortKey="Diehl, J A" uniqKey="Diehl J">J.A. 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Klenk</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Jeong, Yong Seok" sort="Jeong, Yong Seok" uniqKey="Jeong Y" first="Yong Seok" last="Jeong">Yong Seok Jeong</name><name sortKey="Kim, Ji Young" sort="Kim, Ji Young" uniqKey="Kim J" first="Ji Young" last="Kim">Ji Young Kim</name><name sortKey="Kim, Man Su" sort="Kim, Man Su" uniqKey="Kim M" first="Man Su" last="Kim">Man Su Kim</name><name sortKey="Koo, Eung Seo" sort="Koo, Eung Seo" uniqKey="Koo E" first="Eung Seo" last="Koo">Eung Seo Koo</name><name sortKey="Lyoo, Hey Rhyoung" sort="Lyoo, Hey Rhyoung" uniqKey="Lyoo H" first="Hey Rhyoung" last="Lyoo">Hey Rhyoung Lyoo</name><name sortKey="Park, Soo Young" sort="Park, Soo Young" uniqKey="Park S" first="Soo Young" last="Park">Soo Young Park</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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